A note was posted in the Release Notes - but I thought I'd respond directly here.
If you are receiving CRC crashes to desktop - it is because you are playing Open Beta with Closed Beta data. I'm in the same boat on my PC at home.
Here's are a few options for those from Closed Beta who are having this issue.
a) Steer clear of Exploration Content - or suffer the random chance you'll get a bad map (it is random - I've done many missions so far - and about half crash).
b) go into your installation directory (such as c:\program files\cryptic studios\star trek online\piggs\) and delete any bins.hoggs and textures.hoggs you find. Then repatch. The patch will be large. Mine's sitting at 9gigs and chugging along.
c) go to the downloads page and get the ST.0.20100108a.0 Open Beta basline from a download site. then patch up.
Wish there was a better way - I'm really enjoying the Exploration content (because its something new all the time and levels to you) - but its a drag when you get the crash.
a me e' toccato farlo non so se ha fissato il tutto in quanto dopo la patch era tardi e son andato a nanna.
Vi aggiorno se ho nuove info.